Title: Enhancing mRNA Translation Efficiency through Trinucleotide Cap Modifications

Date: May 16, 2024

Time: 08:30 a.m. Eastern Time

Featured Speaker:

Larry (Jiancun) Zhang

Founder & Chairman, Guangzhou Henovcom Biosciences Co., Ltd.

Key points:

- LZCap^?AG(AM) and LZCap^?AG(FM) capped mRNAs demonstrate outstanding protein expression efficiency across various cell lines;

- mRNAs with LZCap^?AG(AM) and LZCap^?AG(FM) demonstrate improved pharmacokinetic profile observed in rats and beagle dogs;

- FAM, Cy3, Cy5, Cy7 labeled mRNA can be obtained directly through a one-pot IVT process and protein expressions still occurred with these modifications;

- Cy5-labelled mRNA can be used for tracing of mRNA by cell flow and fluorescence confocal tools to facilitate accurate screening of delivery vehicles and formulations, and Cy7-labelled mRNA can be used for mRNA tracing in vivo in live animals.

TIDES USA: Oligonucleotide & Peptide Therapeutics

Venue: Boston, MA, USA. Hynes Convention Center

Date: May 14, 2024 - May 17, 2024

Each year, the TIDES conference scientific agenda includes 150+ of the industry's top scientists to present the latest science and industry updates across the entire spectrum from discovery, preclinical, clinical development through CMC, Manufacturing and commercialization of therapeutics and vaccines for oligos, peptides, mRNA and genome editing products.?

Conference Website：https://informaconnect.com/tides/